HOTAIR and cancer: As reported in our article1, the G allele of HOTAIR rs1899663 G>T polymorphism has been considered protective in some studies.2 But, there are studies in the literature reporting that the T allele of HOTAIR rs1899663 G>T polymorphism increases the risk of cancer.3 Contrary to these results, Hassanzarei et al4 reported that the T allele of rs1899663 G>T polymorphism of HOTAIR gene was protective against breast cancer in the Iranian population.