BIRC5 and neoplasm: Therefore, to clearly illustrate the immune‐relevant function of Birc5 in regulating HCC tumor immune microenvironment, we still need to further answer which type of MDSCs contribute to the immunosuppressive tumor microenvironment and by which signaling pathways, cytokines, and chemokines, Birc5 impacts the amplification and infiltration of MDSCs in tumor tissue, as well as the clinical significance of targeting Birc5 in immunotherapy of HCC.