Even though concrete evidence is still missing on the relation between sex hormones and ACE2/Ang-(1-7)/MasR axis with COVID-19 progression, the treatment with estrogens could have vasculo-protective and neuroprotective effects by reducing signs of vascular impairment, reducing platelet aggregation, modulating molecular pathways on endothelial cells, regulating vascular tone, and reducing thrombotic risk and inflammatory process (Fig. 3B) [41, 45, 46, 64, 68, 69]. The gene discussed is ACE2; the disease is COVID-19.