The RAS imbalance causes the activation of ACE/AngII/AT1R, causing a hyperinflammatory state and pulmonary injury, thus, inducing various signaling pathways, including ERK, JNK/MAPK as well as PKC and suppressing the anti-inflammatory alternative pathway ACE2/Ang-(1-7)/MasR being this the ACE2 paradoxical action in COVID-19 (Fig. 2) [24, 25]. Here, ACE2 is linked to COVID-19.