The binding of Ang II and AT1 receptor increases blood pressure by inducing vasoconstriction, while the overexpression of ACE2 attenuated hypertension through the upregulation of the expression and phosphorylation of nitric oxide synthase (NOS), increasing, in turn, nitric oxide (NO) release (Fig. 2) [65]. The gene discussed is ACE2; the disease is hypertensive disorder.