This is supported by Hilliard et al. who showed evidence that 17β-estradiol can modulate the RAS by increasing the ACE2/Ang-(1-7)/MasR expression, plus they showed that this system was upregulated in premenopausal females and can protect against hypertension, renal and cardiovascular diseases in comparison to men. The gene discussed is ACE2; the disease is Hypertension.