TP53 and cancer: Our laboratory has previously shown that Az1 is a negative regulator of DNp73 (Dulloo et al., 2010), an oncoprotein of the p53 (TP53) tumor-suppressor family, that is overexpressed in a variety of cancers and the expression of which leads to resistance to a variety of chemotherapeutic drugs and metastasis (Müller et al., 2005; Steder et al., 2013).