In particular, the overexpression of PD‐1/PD‐L1 and the epithelial–mesenchymal transition have received increasing attention.14, 15 According to the literature, RCC‐R has a higher proportion of neutrophilic inflammation, whereas RCC‐S has a higher degree of dedifferentiation and peripheral nerve infiltration.14 This evidence concerns the gene PDCD1 and renal cell carcinoma.