Infections in NIH III mice (SCID mice deficient in NK cells) were found to be more disseminated than SCID mice with normal NK cell function (Mead et al., 1991) and infections were more severe in Rag2-/- gammaC-/- mice (T and B cells, lack NK cells) than Rag2-/- mice (Barakat et al., 2009a). This evidence concerns the gene RAG2 and infection.