We found that (i) the conventional T cell response in prostate cancer survivors is similar to non-cancer controls; (ii) overall CD57 frequency in CD8+ T cells is lower with ADT, suggesting reduced maturation in the absence of testosterone, yet higher perforin expression levels were observed that may represent a compensatory response; and (iii) UTCs demonstrate increased counts with acute exercise in all groups, with NKT-like cells showing preferential mobilization whereas MAIT cells did not. Here, CD8A is linked to Familial prostate cancer.