Interestingly, using the synthetic lethal screening modality in vitro, Stockwell found that the introduction of oncogenic RAS into cancer cells leads to increased levels of cellular labile iron pool by upregulating transferrin receptor gene TfR1 and downregulating ferritin genes FTH and FTL. This non-apoptotic cell death is inhibited by iron chelator, which indicates that it is iron-dependent. The gene discussed is TFRC; the disease is cancer.