Intriguingly, FH-inactivated renal cell carcinoma (HLRCC) exhibits oxidative stress promotion, and metabolic alteration, and increased sensitivity to ferroptosis through the mechanisms of inducing fumarate accumulation, the succination of GPX4 proteins at the C94 site, and the inhibition of GPX4 function (54). Here, GPX4 is linked to renal cell carcinoma.