GPX4 deficient CD8+ and CD4+T cells fail to withstand virus and parasite infections (115), and in the chicken bursa of the Fabricius model, selenium deprivation elicits a decrease in GPX4, the downregulation of IL-2, IL-6, IL-8, IL-10, IL17, IL-1β, IFN-α, IFN-β, and IFN-γ compared with the controls, and in the bursa having a higher TNF-α level than the controls (120). Here, GPX4 is linked to biological process involved in symbiotic interaction.