GVHD following liver transplantation (LT-GVHD) is a rare complication, associated with bone marrow failure and a hyperinflammatory state; in a case series of 9 patients where 7 bone marrow samples were available for next generation sequencing, DNMT3A mutations were found in 5 out of 7 samples, as compared to 1 of 6 in a LT-non-GVHD cohort (63). The gene discussed is DNMT3A; the disease is graft versus host disease.