Two smaller studies also examined the CHIP-alloreactivity link: A single-center study found increased risk of acute GVHD but not chronic GVHD and no differences in incidence of relapse; notably, this study included a large number of high-risk patients, with over half of the cohort having active disease at the time of transplantation (61). This evidence concerns the gene STUB1 and chronic graft versus host disease.