PYCARD and psoriasis: In psoriasis patients, mRNA of inflammasome-associated genes was found increased in lesional skin compared to non-lesional skin and skin of healthy controls, including ligand sensors AIM2 (149), IFI16 (149), NLRP3 (150), NLRP10 (149), inflammasome components PYCARD (encoding ASC protein) (149) and CASP1 (150), the effector cytokines IL1B (149, 150) and IL18 (148, 151) as well as regulatory CARD18 (149).