Peripheral blood of psoriasis patients (compared to healthy controls):• Increased ASC, IL-1β and IL-18 levels in untreated patients• Increased NLRP1 and NLRP3 protein expression in peripheral blood CD4+ lymphocytes, CD14+ monocytes and CD16+ neutrophils• Increased AIM2 protein expression in CD14+ monocytes and CD16+ neutrophils. Here, NLRP1 is linked to psoriasis.