Psoriasis skin lesions (compared to skin of healthy controls):• Increased AIM2, IFI16, NLRP3, NLRP10, PYCARD, CASP1, CASP5, IL1B, IL18 and CARD18 mRNA expression in lesional skin• Increased NLRP3, NLRC4, IFI16, AIM2, ASC, caspase-1, inactive caspase-5, IL-1β and IL-18 protein expression in lesional skin• Increased NLRP1, NLRP3, AIM2, PYCARD and CASP1 mRNA expression and CARD18 protein expression in lesional as well as non-lesional skin• DNA fragments detectable in the cytosol of keratinocytes from psoriatic skin lesions. The gene discussed is CASP1; the disease is psoriasis.