Vitiligo skin lesions (compared to skin of healthy controls):• Increased NLRP1 protein expression in perilesional skin of patients with progressive disease, particularly in the entire epidermis, also compared to lesional skin of vitiligo patients• In contrast to finding above: Increased NLRP1 protein expression restricted to Langerhans cells in leading edge vitiligo skin lesions• Increased NLRP3 and IL-1β protein and mRNA expression in perilesional skin of patients with progressive disease, also compared to patients with stable vitiligo disease. The gene discussed is NLRP3; the disease is vitiligo.