The role of NSUN6 in cancer development remains unclear, but studies have shown that NSUN6 acts as a protective factor against triple-negative breast cancer (TNBC) (36), pancreatic cancer (31), testis cancer (79), thyroid cancer (79) and ovary cancer (79) but is a risk factor for CRC (80, 81). Here, NSUN6 is linked to colorectal carcinoma.