Current studies have revealed that NSUN3 expression is upregulated in patients with low-grade glioma (63) and head and neck squamous cell carcinoma (HNSCC) (64), and NSUN3-mediated m5C modification of tRNA enhances metastasis by stimulating the translation of mitochondrial mRNA (27). Here, NSUN3 is linked to head and neck squamous cell carcinoma.