After m5C modulation and binding to m5C readers, such as YBX1, the transcriptional activity of PIK3R1, PCYT1A and FOXC2 mRNA was increased, while tumor-suppressive p57Kip2 mRNA was destabilized as a result of m5C modulation in the 3’-UTR. This evidence concerns the gene FOXC2 and neoplasm.