The miR-140–3p affects bone marrow stromal cells (BMSCs) in degenerative intervertebral disc disease (IVD) by directly targeting KLF5 and interacting with the N–cadherin/MDM2/Slug axis, thereby regulating regenerative effects in degenerative IVD (48). This evidence concerns the gene KLF5 and intervertebral disk degenerative disorder.