Results showed that conditioned medium from FAP-over-expressed LX2 cells could decrease the expression of M1 markers like iNOS, TNF-α and IL-1β but increase the expression of M2 markers like IL-10 in macrophages as compared to NC group, transforming the macrophages into M2 pro-tumor phenotype (Figure 7E). Here, NOS2 is linked to neoplasm.