Regretful, these results were obtained only focusing on FAP that expressed in fibroblasts, though previous evidence has demonstrated that fibroblasts contribute to main source of FAP in tumor tissues, FAP could also be detected in other kinds of cells like tumor cells, endothelial cells, monocytes, lymphocytes at lower concentration (36, 37), in this regard, their effects in tumor progression cannot be neglected and required more experiments for analysis. This evidence concerns the gene FAP and neoplasm.