A meta-analysis of 8 different studies reported HLA-DRB1*07 and HLA-DRB1*12 associations with the risk of HCC, while HLA-DRB1*07, HLA-DRB1*12 and HLA-DRB1*15 alleles were associated with significantly increased risks of HCC in Asians (27). The gene discussed is HLA-DRB1; the disease is hepatocellular carcinoma.