However, when we performed age-matched HLA association testing with 49 PBC with HCC patients and 49 PBC without HCC patients (Supplementary Table 7), HLA-DRB1*09:01:02, HLA-DQB1*03:03:02, HLA-DRB1*09:01:02-HLA-DQB1*03:03:02 remained borderline significant after adjusting for multiple comparisons. This evidence concerns the gene HLA-DQB1 and hepatocellular carcinoma.