Studies have shown that overexpression of endogenous SOD or administration of exogenous SOD effectively prevents acute organ injury and improves the survival of septic animals.[17, 18, 19, 20, 21, 22] Although natural SOD holds promise for treating sepsis, it is unsatisfactory in practical applications due to its instability under non‐physiological conditions and susceptibility to proteolytic enzymes. The gene discussed is SOD1; the disease is Sepsis.