TIGIT expression on tumour-infiltrating lymphocytes (TILs) in non-small cell lung cancer (NSCLC) is upregulated when compared with healthy controls, but moreover, the expression dynamics of TIGIT exceed that of PD-1 in that TIGIT mRNA increased more rapidly than PD-1 mRNA, and TIGIT+ CD8+ T cells upregulated PD-1 more rapidly than TIGIT- CD8+ T cells in NSCLC patients [28]. The gene discussed is CD8A; the disease is neoplasm.