CD155 ligation with DNAM-1 results in its phosphorylation at Tyrosine 319 by Src kinases enabling its ubiquitination and clearance from the cell surface, and indeed specific mutations such as Y319F prevent phosphorylation and degradation of DNAM1, and thus enable synergism with anti-PD-1 and enhanced anti-tumour immunity in murine models (MC38 and B16) [36]. Here, CD226 is linked to neoplasm.