Intriguingly, this upregulation of HOX genes is shared with NUP98::NSD1, DEK (DEK proto-oncogene)::NUP214 (nucleoporin 214), and NPM1 (nucleophosmin 1) mutated cases, suggesting HOXA and HOXB overexpression is a common alteration in leukemia development (de Rooij et al., 2013; Noort et al., 2021). Here, NUP98 is linked to leukemia.