The cytogenetically cryptic translocation t(11;12)(p15;q35) (resulting in NUP98::KDM5A fusion, also known as NUP98::JARID1A or NUP98:: RBP2) was initially identified in pediatric AMKL in 2006 (van Zutven et al., 2006). Here, KDM5A is linked to acute megakaryoblastic leukemia.