CBFA2T3::GLIS2 is not specific to AMKL and occurs in diverse morphologic subtypes of de novo AML (except for acute promyelocytic leukemia (APL) and leukemia with erythroid differentiation), overall found in approximately 8.4% of cytogenetically normal AML cases (Masetti et al., 2013a; Smith et al., 2020). The gene discussed is GLIS2; the disease is acute myeloid leukemia.