Mice transplanted with NUP98::KDM5A bone marrow progenitors develop CD34+CD117+ AML, characterized by transcriptional upregulation of lineage-specific factors (HOXA, GATA3, MEIS1, EYA, PBX1 (pre-B-cell leukemia transcription factor 1), and epigenetic activation of the HOXA gene cluster (Wang et al., 2009). Here, PBX1 is linked to acute myeloid leukemia.