The median age of AMKL patients carrying NUP98::KDM5A is lower than in AML overall (1.8–1.9 years, range: 0.7–12 years) (de Rooij et al., 2016; de Rooij et al., 2017; Noort et al., 2021). This evidence concerns the gene KDM5A and acute myeloid leukemia.