GLIS2 and acute myeloid leukemia: GLIS2 overexpression in MOZ (monocytic leukemia zinc finger protein):TIF2 (transcriptional intermediary factor 2) leukemic cells promotes their differentiation into mature myeloid cells and delays AML development in mice, indicating that GLIS2 inhibits AML initiation by inducing LSC differentiation (Shima et al., 2018).