The t(1;22)(p13;q13) results in a fusion of the RBM15 (the RNA-binding motif protein 15) gene, also named as OTT (one twenty-two) located on chromosome 1p13 to the MKL1 (megakaryoblastic leukemia-1) gene, also named as MAL (megakaryocytic acute leukemia) or MRTFA (myocardin-related transcription factor A) located on chromosome 22q13 (Ma et al., 2001; Raffel et al., 2007). Here, RBM15 is linked to acute megakaryoblastic leukemia.