GATA1 downregulation, ERG (ETS-related gene) upregulation, and activation of super enhancer elements may impair megakaryocytic differentiation and increase abnormal self-renewal of leukemic cells in AMKL associated with CBFA2T3::GLIS2 (Thirant et al., 2017a; Benbarche et al., 2022). The gene discussed is ERG; the disease is acute megakaryoblastic leukemia.