NT5E and preeclampsia: While a study by Iriyama et al. did not show a difference in CD39 mRNA levels, but demonstrated significantly elevated mRNA, protein level and enzyme activity of CD73 in placentas from preeclampsia patients at term (Iriyama et al., 2015) patients at term, another recent study by Zhu et al. described significantly decreased placental CD39 expression in pregnancies complicated with late-onset preeclampsia (Zhu et al., 2018).