Our study showed that spermatozoa from TTC12-variant carriers exhibited impaired flagellar motility and deficiency of ODA and IDA, consistent with the previous observations in two unrelated infertile male adults with homozygous variants in TTC12. However, sperm morphology examination revealed additional multiple morphological abnormalities of the sperm flagella (MMAF) feature. This evidence concerns the gene TTC12 and Infertility.