LEF1 and Hand-foot syndrome: When co-cultured with human DPCs, one hiPSC-derived EPC line upregulated hair-associated genes KRT75, MSX2, LEF1, and TRPS1. Upregulation of DPC-related genes ALPL, BMP4, and LEF1 was also observed in the co-cultured DPCs, indicating cross-talk between epithelial and mesenchymal components of HFs (Veraitch et al., 2013).