Similar to human colorectal cancers (Kwok et al., 2018), MALAT1 is slightly downregulated in the murine colonic polyps compared to healthy tissues, a pattern also observed in genes encoding known colorectal cancer tumor suppressor molecules, such as Mbd1 and Tmigd1 (Qi and Ding, 2017; Mu et al., 2022) (Figure 4A). Here, MBD1 is linked to neoplasm.