IRF1 and neoplasm: There existed differential expression of 16 PRGs between LIHC and adjacent normal samples, among which the expression of CASP8, FADD, GSDMD, PARP1, and TRADD was upregulated, whereas that of AIM2, CASP1, CASP6, CASP7, IRF1, NLRP3, RIPK1, RIPK3, TAB2, TAB3, and ZBP1 was downregulated in tumor samples (p < 0.05) (Figure 1D).