Additionally, Wang et al. observed that FGFR2+/S252W mutant mice, another Apert syndrome mouse model with FGFR2 gain-of-function mutation, showed proximate OFs of two parietal bones and abnormal osteoid deposited between them when compared with controls; while the interfrontal suture of mutant mice exhibited a broad gap between the OFs of frontal bones when compared with control ones (Wang et al., 2005). This evidence concerns the gene FGFR2 and Apert syndrome.