Concomitantly, they found that FGFR2+/P253R mutant mice, another FGFR2 gain-of-function mutation that commonly occurs in patients with Apert syndrome, had cranial features that resembled those shown in FGFR2+/S252W mutant mice (Wang et al., 2010). Here, FGFR2 is linked to Apert syndrome.