Recently, Min Swe et al. found that Lrp5 and Lrp6, co-receptors of Wnt/β-catenin signaling, were aberrantly activated in the developing coronal sutures of Apert syndrome (FGFR2+/S252W) mouse models (Min Swe et al., 2021). The gene discussed is FGFR2; the disease is Apert syndrome.