SIX2 and Saethre-Chotzen syndrome: Additionally, Six2+ SMSCs were reduced in the coronal suture of E14.5 and E15.5 embryos from a mouse model of Saethre-Chotzen syndrome (Twist+/−; Tcf12+/−) with coronal synostosis, suggesting the potential functions of Six2+ SMSCs in suture patency (Farmer et al., 2021).