Compared with other sutures, craniosynostosis mainly occurs in the coronal sutures in FGFR gain-of-function mutant animal models, such as FGFR2+/S250W and FGFR2+/S252W transgenic mice, and FGFR3Y367C/+ mutant murine models (Wang et al., 2005). This evidence concerns the gene FGFR2 and craniosynostosis.