ADAD2 and Infertility: Similar to the ADAD2-mutation-carrying patients, the Adad2Mut/Mut male mice were infertile (Supplementary Fig. S3D) with significant reductions in testicular size (Supplementary Fig. S3A and B) and an absence of spermatozoa in the epididymides (Fig. 3A; Supplementary Fig. S3C).