Some studies suggested that BRCA1 or BRCA2 mutations were involved in infertility or POI (Oktay et al., 2010; Titus et al., 2013; Wang et al., 2014; Lambertini et al., 2018; Son et al., 2019; Turan et al., 2021). The gene discussed is BRCA1; the disease is Infertility.