To evaluate immune-mediated effects, a new mouse syngeneic GSC model was developed; PDGF-B transduced BALB/c neural progenitor cells were implanted orthotopically, gliomas were harvested, and isolated GSCs were transduced with human HER-2 (mHGGpdgf-HER2) (Reisoli et al., 2012). Here, ERBB2 is linked to central nervous system cancer.