RPS3 and central nervous system cancer: Because of these properties, ICP6 mutations have been combined with other mutations to enhance oHSV safety, especially in the brain, and glioma specificity; including, 1716-6 (γ34.5Δ ICP6-) from HSV1716 (γ34.5Δ), MG18L (Us3- ICP6-) from R7041 (Us3-), and Δ68H-6 (γ34.5-BBDΔ ICP6-) from Δ68H (γ34.5-BBDΔ) (Peters and Rabkin, 2015).