VEGFA and neoplasm: The anti-angiogenic activity of IL-12 was examined in vitro, where conditioned media from G47Δ-mIL12 infected glioma cells or GSCs inhibited endothelial tube formation, and in vivo where it extended survival of hGSC-derived tumor-bearing mice, coincident with decreased neovasculature and VEGF expression (Zhang et al., 2013).