Later, it was found that loss of m6As within IFNβ1 mRNA due to METTL3 or DF2 depletion leads to the stabilization of IFNβ1 mRNA and a stronger antiviral response during HCMV infection, suggesting that m6As may serve as a negative regulator of the antiviral IFN response (Winkler et al., 2019). This evidence concerns the gene IFNB1 and cytomegalovirus infection.