Finally, increased H3K27me3 level has been also identified in melanomas with mutated NRAS, second most frequent driver mutation in melanoma, and increased PRC2 activity has indirectly triggered the expression of mesenchymal markers and transcription factors such as zinc finger E-box binding homeobox 1 (ZEB1) and downregulation of epithelial protein E-cadherin (Terranova et al., 2021). This evidence concerns the gene CDH1 and melanoma.