For instance, growth arrest specific 5 (GAS5), a long non-coding lncRNA downregulated in advanced melanoma, recruits E2F transcription factor 4 (E2F4) to EZH2 promoter, which results in EZH2 repression in melanoma, and this repression correlates with the upregulation of cyclin-dependent kinase inhibitor 1C (CDKN1C) (Xu et al., 2020b). This evidence concerns the gene CDKN1C and melanoma.