This lncRNA cooperates with EZH2 to negatively regulate the expression of p21 tumor suppressor (Ni et al., 2017), a product of CDKN1A. FALEC downregulation has been shown to trigger apoptosis, block EMT-like process and inhibit proliferation in melanoma cell lines (Ni et al., 2017). This evidence concerns the gene CDKN1A and melanoma.