EZH2 and breast cancer: With the use of 3D modeling prediction programs enabling identification of several hairpin loop structures in the HOTAIR molecule that might serve as docking sites for several small-molecule compounds, followed by in silico high-throughput screening to find interacting ligands, Ren et al. (2019) identified a compound AC1NOD4Q that selectively blocks the HOTAIR-EZH2 interaction in glioma and breast cancer cell lines.