It has been demonstrated that LNMAT1 promotes migration and invasion of melanoma in vitro and in vivo by cooperating with EZH2 to inhibit the expression of cell adhesion molecule 1 (CADM1), a recognized tumor suppressor that inhibits the expression of MMP-2 and MMP-9 matrix metalloproteinases (You et al., 2014). The gene discussed is EZH2; the disease is melanoma.