It has been found that re-expression of MEG3 limits EMT-like phenotype in melanoma through upregulation of E-cadherin by targeting miR-21 (Wu et al., 2020) and miR-499-5p, which negatively regulates tumor suppressor CYLD lysine 63 deubiquitinase (Long and Pi, 2018). The gene discussed is MEG3; the disease is melanoma.