Previous studies have demonstrated the crucial role of ACE2/Ang/MAS axis in activating the Akt signaling to manage oxidative stress, inflammation, and hepatic steatosis (Cao et al., 2016) and that Akt inhibitors significantly reduce the ACE2 mediated lipid metabolism, thereby providing insights to manage the SARS-CoV-2 infection-induced metabolic changes in host cells (Cao et al., 2016). Here, ACE2 is linked to fatty liver disease.