NFE2L2 and COVID-19: Similarly, the Nrf2-dependent antioxidant pathway have been found to be suppressed in the biopsies of COVID-19 patients but interestingly the Nrf2 agonists like dimethyl fumarate (DMF) and 4-ocy-itaconate (4-OI) were reported to induce cellular antiviral effects that could inhibit the replication of SARS-CoV-2 by suppressing the pro-inflammatory response of the SARS-CoV-2 (Olagnier et al., 2020).