The abundance of lncMGC RNA is relatively low (three to four copies/cell in the control condition); however, an increase in lncMGC RNA by TGF-β or HG causes a significant increase of ∼40 miRNAs in the cluster and showed a significant impact on the development of DKD (Kato et al., 2016). This evidence concerns the gene TGFB1 and diabetic kidney disease.