The microRNA-379 (miR-379) megacluster of miRNAs and its host transcript, lncRNA and lnc-megacluster (lncMGC), are regulated by transforming growth factor-β1 (TGF-β), increased in the glomeruli of diabetic mice, and promote features of early DKD (Kato et al., 2016). This evidence concerns the gene TGFB1 and diabetic kidney disease.