CCL2 and neoplasm: The results of qRT-PCR analysis on tumor tissues isolated from mouse models showed that in the treated group, CVC could significantly downregulate mRNA levels of CCR2, CCL2, VEGF, vimentin, c-Myc, and NF-κB, and IL33 compared to the control group (43% reduction for CCR2, 45% for CCL2, 38% for VEGF, 38% for NF-κB, 59% for c-Myc, 28% for vimentin, and 18% for IL33) (Figure 6).