The univariable analysis using the training set showed that duration of symptoms (p < 0.001), vomiting (p = 0.001), bloody stools (p < 0.001), abdominal mass (p < 0.001), temperature (p = 0.002), WBCs (p < 0.001), PLTs (p < 0.001), CRP (p = 0.006), CK-MB (p = 0.041), long-axis diameter (p = 0.004), poor prognostic signs by ultrasound (p < 0.001), absence of blood flow in the intussusception (p = 0.006), serum Na (p < 0.001), mental state (p < 0.001) and intussusception location (p < 0.001) were the significant factors for surgical intervention of intussusception. This evidence concerns the gene CRP and Intussusception.