IL18 and Alzheimer disease: Our data explored that A allele, AA genotype and AG + AA genotype of IL-18 rs7106524, as well as IL-18/CAA haplotype consisting of rs187238, rs360718 and rs7106524 were associated with a high risk of severe AD, suggesting the genetic polymorphisms of IL-18 rs7106524 might be used as potential predictors of AD severity.