Meanwhile, comparison of the patients who had a G-C4d score of 1 vs. those with a score of 2 showed that the mean age, serum creatinine, blood urea nitrogen, hematuria, serum C3 and C4, as well as proportions of hypertension and serum anti-dsDNA detection were not significantly between the two groups of patients. The gene discussed is C3; the disease is Hypertension.