When analysis was limited to first cycles only within each OS protocol, the unadjusted differences in HCG positivity and CP were in the same direction in cycles utilizing OM but did not reach statistical significance (7.6% vs. 15.5%, p = 0.062; 5.1% vs. 12.5%, p = 0.054; for the FROZEN and FRESH groups, respectively). Here, CP is linked to ocular melanoma.