MKI67 and neoplasm: The staining results revealed that the activated macrophages (FaDu+THP1+IL4) notably increased the expression of Ki67 in tumor tissues, and the knockdown of LINC01569 in THP1 cells (FaDu+THP1-LINC01569 siRNA+IL4) abrogated the effects of activated macrophages on the expression of Ki67, which indicated that tumor growth could be reinforced by IL-4-exposed THP1 cells, and the protumour effect of M2 macrophages could be reversed by treatment with LINC01569 siRNA (Fig. 7D).