It is reported that HDAC3 in the cSCC is up-regulated in cSCC, to compare with the normal dermal tissue, and its inhibitor Rg3 treatment inhibited the epithelial mesenchymal transformation (EMT) in cSCC cell, indicated that HDAC3 maybe serve as a target for cSCC therapy 27. This evidence concerns the gene HDAC3 and skin squamous cell carcinoma.