In addition to HDGC, analyses of somatic mutations in gastric adenocarcinomas showed a higher frequency of altered CDH1 in younger patients 19-21, whereas late-onset gastric adenocarcinoma samples did show a higher genomic instability leading to more chromosomal instable tumors and fewer genomically stable tumors (associated with poorly cohesive growth) according to the TCGA molecular classification 19, 22. The gene discussed is CDH1; the disease is gastric adenocarcinoma.