CDH1 and Familial gastric cancer: In addition to HDGC, analyses of somatic mutations in gastric adenocarcinomas showed a higher frequency of altered CDH1 in younger patients 19-21, whereas late-onset gastric adenocarcinoma samples did show a higher genomic instability leading to more chromosomal instable tumors and fewer genomically stable tumors (associated with poorly cohesive growth) according to the TCGA molecular classification 19, 22.