Functional enrichment analysis found that STXBP5-AS1 may be involved in cell junction, DNA replication, apoptosis, cell cycle, metastasis, TP53, Wnt, mTORC1, MCM, NOTCH4, transforming growth factor beta receptor, and cGMP-PKG signaling pathways and biological processes in COAD. Here, NOTCH4 is linked to colon adenocarcinoma.