Similarly, the mRNA expression of PRAP1 was also increased in different types of human CRC cell lines, including HCT-116 (P=0.0011), HT-29 (P<0.0001), LOVO (P=0.0001), and SW480 (P=0.0010) cells, when compared with that in the untransformed (normal) colon cells CRL-1790, among which the most prominent was HCT-116 cells (Fig. 1B). Here, PRAP1 is linked to colorectal carcinoma.