Transduction with sh-SLC5A3 (seq3) significantly induced apoptosis and increased the number of TUNEL-positive nuclei in pCCa-2 and pCCa-3 primary cervical cancer cells and HeLa cells (Figure 4G) but did not promote CASP3 activation (Figure 4H) or induce cell apoptosis (TUNEL assays, Figure 4I) in HCerEpC1 and Ect1/E6E7 epithelial cells. The gene discussed is CASP3; the disease is cervical cancer.