Importantly, PLK4 expression in CRC samples was positively associated with proliferation (p < 0.0001, Figure S2B) and higher expression of PLK4 usually exhibited an activated cell cycle (p=0.040, Figure S2C), enhanced invasiveness (p = 0.006, Figure S2D) as well as metastasis (p < 0.0001, Figure S2E). The gene discussed is PLK4; the disease is colorectal carcinoma.