In accordance with previous studies, WB analysis showed a prominently increased p-p38 level and a decreased p-ERK level caused by PLK4 depletion, and PLK4-depleted dormant-phenotype CRC cells alleviated the expression of important indicators of cell proliferation and cell cycle status, such as PCNA, CDK4 and CDK6 (Figure 1C). This evidence concerns the gene CDK6 and colorectal carcinoma.