As an intracellular tetrapyrrole-binding protein, Hebp1 is known to be involved in heme regulation, biosynthesis, and transport.1, 27 A recent study that screened for proteomic changes associated with early Alzheimer's disease (AD) stages by Yagensky et al. demonstrated that Hebp1 is predominantly expressed in neurons, interacts with the mitochondrial contact site complex, and is involved in heme-induced neuronal death in AD.3 However, the biological functions of Hebp1 in the peripheral nervous system remain unclear. This evidence concerns the gene HEBP1 and early-onset autosomal dominant Alzheimer disease.