As mentioned above, miR-503-5p promoted proinflammatory response and atherosclerosis development by regulating smurf1, smurf2, and Smad7; thus, hsa_circ_0072387 may suppress lipid synthesis and pro-inflammatory response by regulating miR-141-3p/YWHAG and PTEN axis, miR-503-5p/smurf1, smurf2, Smad7 axis. The gene discussed is SMAD7; the disease is atherosclerosis.