Furthermore, since HDAC1 and 2, belonging to class I HDACs, and HDAC4 and 5, belonging to class II HDACs, increase in an in vitro model of stroke 30, 39, we investigate the specificity of HDAC9, among HDACs isoforms, in the modulation of TfR1 and GPX4 after ODG/Rx. The gene discussed is GPX4; the disease is Stroke.