Several downstream signaling pathways are reported, in which PBX1 acts as a pioneer transcription factor to mediate the binding of FoxC1 to ZEB2 promoter in oesophageal cancer cells24, or to promote 13‐cis retinoic acid‐mediated differentiation in neuroblastoma25. The gene discussed is FOXC1; the disease is carcinoma of esophagus.