Moreover, in patients undergoing angioplasty, nano‐curcumin at the same dose caused a significant decrease in hs‐CRP levels (Helli et al., 2021).Besides, the systematic review had shown that curcumin improved the severity of inflammation including asthma, inflammatory bowel disease, and juvenile idiopathic arthritis (Heidari et al., 2022). This evidence concerns the gene MAP3K14 and juvenile idiopathic arthritis.