Compared with the blank control group, both the two standard H. pylori strains (SS1 and 26695) infection significantly increased the mRNA expression of IL‐6 (p < .0001), IL‐8 (p < .0001, p < .05) and CXCL‐1 (p < .001, p < .0001) in GES‐1 cells, while the tartary buckwheat flavonoids group decreased their mRNA expression (IL‐6: 60.7%, 72.0%; IL‐8: 79%, 92.40%; CXCL‐1: 82.3%, 89.2%). Here, IL6 is linked to infection.