VEGFA and cancer: Chen group developed a gene delivery system with on‐surface crosslinkers to overcome a series of biological barriers.[58] As shown in Figure 8A, the delivery system was first assembled by polyethyleneimine (PEI) and poly‐l‐glutamate (PLG) to carry a plasmid DNA (pDNA) which expressed small hairpin RNA (shRNA) that targeted vascular endothelial growth factor (VEGF) to execute anti‐cancer effect.