ERN1 and Insulin resistance: In addition, they performed in vitro experiments to investigate the insulin sensitization impact of naringenin on HCVCP-infected Huh-7.5.1 cells with IRE1 overexpression or knockdown and determined that naringenin prevented HCVCP-induced endoplasmic reticulum stress, reduced IRE1 downstream gene expression and splicing activity, and prevented IRE1 expression, which resulted in improved insulin resistance.